RR408 - Genetic variation in susceptibility to chronic effects of organophosphate exposure

A case-referent study was carried out to investigate whether the ability to metabolise and detoxify organophosphates differed between sheep dippers with self-reported chronic ill-health (cases) and healthy dippers (referents) of similar age and with a similar dipping history. Cases and referents were interviewed by a study nurse and information on their current health and occupational history obtained. A blood sample was also taken, DNA extracted and polymorphisms in genes associated with organophosphate metabolism determined.

This report and the work it describes were funded by the Health and Safety Executive (HSE). Its contents, including any opinions and/or conclusions expressed, are those of the authors alone and do not necessarily reflect HSE policy.

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Updated 2021-04-20