RR190 - Inter-individual variability in the interpretation of biological monitoring guidance values
The incorporation of inter-individual differences in the setting
of occupational exposure standards such as biological monitoring
guidance values has been studied by investigating the possibility
of transferring in vitro measurements of variability in metabolism
to the in vivo situation. The generation of generic information on
the activity of two major enzymes systems considered important in
the metabolism of industrial chemicals, was investigated by using
'probe' substrates. Variability in the activities of
cytochromes P450 1A2 and 2E1, and the cytosolic glutathione
transferases µ and q were measured in human hepatocytes,
hepatic microsomes and cytosols. Variability in the metabolism of
styrene, a chemical of industrial importance, was also measured for
comparison. The ability to use in vitro data to simulate in vivo
variability was investigated by incorporating in vitro data into a
PBPK model for styrene.
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