RR15 - In vitro determinants of particulate toxicity: The dose-metric for poorly soluble dusts
Rats exposed to high airborne mass concentrations of low
toxicity poorly soluble particles (LTPSP) have developed lung
disease such as fibrosis and lung cancer. These particles are
regulated on a mass basis in occupational settings. However, animal
studies have shown ultrafine particles producing stronger
inflammatory effect than fine particles per unit mass. This study
investigates whether the surface area of an LTPSP is a better dose
metric than mass (or volume) for describing the particles'
ability to induce pro-inflammatory effects in vitro. Additionally
it was hoped that the developed in vitro approach would become a
reliable means of screening the toxicity of particles with the
advantages of being less expensive and more ethical than animal
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