CRR 355/2001 The validity and interpretation of neurobehavioural data obtained in studies to investigate the neurotoxic effects of occupational exposure to mixtures of organic solvents

Psychological performance tests have been used for a number of years in largescale studies to investigate the neurotoxicity of solvents in occupational settings. Concerns have been expressed about the methodological quality of many of these studies and about the validity and significance of the data reported. The present report addresses two issues in relation to these concerns. Section I investigates the strength of the evidence that long-term, low-level occupational exposure to solvents can result in neurobehavioural effects, which are less severe than those which constitute chronic toxic encephalopathy (CTE). Section II discusses the feasibility of evaluating the significance of any demonstrated effects by reference to the size of effects observed following exposure to other agents.

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Updated 2021-04-14