Introduction to Assessment of Pesticide Toxicology
Brexit: Transition period
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Assessment of effects on human health is a key element of the EU-wide regulation of pesticides, biocides,general chemicals (REACH - (Registration, Evaluation, Authorisation and Restriction of Chemicals)) and chemical classification (CLP). This area of the HSE"s Chemicals Regulation Division (CRD) website provides information relating to the toxicological evaluation of pesticide chemicals with respect to human health. Information relating to CRD"s work on Biocides, REACH, CLP and Prior Informed Consent (PIC) can be found elsewhere on CRD"s Website.
Central to the human health assessment of pesticide chemicals is the toxicological evaluation. This process involves the independent evaluation of data that informs on the human health effects of pesticide chemicals, which is subsequently used to make formal recommendations for use in European regulatory processes. The data are submitted by chemical companies and depending on the chemical can include metabolism and kinetic investigations,single and repeated dose toxicity studies ranging from acute to lifetime via oral, dermal or inhalation routes,tests on mutagenicity and fertility effects and other specific investigative studies.
Toxicological data is used to derive appropriate reference values for use in the human-health risk assessment and to make recommendations on the classification of pesticide active substances for effects on human health.
Specific data may be required for authorisation of plant protection products (PPPs). This includes data that informs on the acute toxicological hazard, dermal absorption values for use in the non-dietary risk assessment and appropriate labelling for human health hazards.