Pesticides methods of analysis

As part of the data requirements for authorising plant protection products and approving active substances, you must submit your methods of analysis. The guidance documents on this page can help you when you are preparing your submission.

You must include methods for determining the active substances and impurities in technical materials and plant protection products, and methods in food, feed and environmental matrices.

You must address both pre-authorisation (data generation) methods and post-authorisation control (monitoring) methods.

Methods should be described fully and validated according to the appropriate guidance. Submissions should include:


This guidance will help you prepare your submission. Some of it was produced by the European Commission but is still relevant. Make sure the methods match the residue definitions in the relevant matrices.

Technical active substance and plant protection products: Guidance for generating and reporting methods of analysis in support of pre- and post-registration data requirements for Annex (Section 4) of Regulation (EU) No 283/2013 and Annex (Section 5) of Regulation (EU) No 284/2013

Guidance document on pesticide analytical methods for risk assessment and post-approval control and monitoring purposes

Technical guideline on the evaluation of extraction efficiency of residue analytical methods

There is useful OECD guidance on their website:

Before submitting your application, check it is complete against the chemistry section of the applications checklist.


Updated 2021-10-29