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RR763 - The development of a web-enabled framework for probabilistic exposure assessments

This report describes the development of a web-based probabilistic model (PROWESE) for predicting the statistical distribution of systemic exposure (dose) to chemicals following occupational use.

Model outputs include:

  1. confidence intervals for percentiles taken from the distribution of systemic exposure (measured in micrograms/kg/day);
  2. confidence intervals for the proportion of workers meeting a minimum Margin of Exposure (with respect to an appropriate toxic threshold); and
  3. graphical output to allow visualisation of the dose distribution. By replacing single worst-case values with distributions representing real variation or uncertainty in exposure parameters, the model enables more realsitic exposure assessment.

This report and the work it describes were funded by the Health and Safety Executive (HSE). Its contents, including any opinions and/or conclusions expressed, are those of the authors alone and do not necessarily reflect HSE policy.

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Updated 2011-02-10