A case-referent study was carried out to investigate whether the ability to metabolise and detoxify organophosphates differed between sheep dippers with self-reported chronic ill-health (cases) and healthy dippers (referents) of similar age and with a similar dipping history. Cases and referents were interviewed by a study nurse and information on their current health and occupational history obtained. A blood sample was also taken, DNA extracted and polymorphisms in genes associated with organophosphate metabolism determined.
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