You can mix 2 or more plant protection products (PPP) in the spray tank for application together as long as
Two specific cases which are unacceptable are:
You may also mix a use a PPP with an adjuvant (a substance that makes the pesticide more effective) if the adjuvant appears on the Authorised List and use is in line with both labels.
Guidance on the safe use of tank-mixes is given in the 'Code Of Practice For Using Plant Protection Products'.
Authorisation holders may however include specific recommendations for tank-mixes on the product label or other literature. In such cases data must be available to demonstrate physical/chemical compatibility and in some cases biological compatibility (efficacy) of the mix. There are two different types of 'tank-mix' each with their own specific requirements:
This is the combination by the user of two or more PPP (or PPPs with an adjuvant) in the same spray tank to reduce the number of spray operations. It is done when the appropriate application timing for the individual PPP coincides, and it is therefore possible to reduce the number of spray operations by applying the products together. A product label 'Compatibility' section may recommend that a product can be mixed with another product. Such tank-mixes must be shown to be physically and chemically compatible. This section of the label may also advise on tank-mixes which are known to be incompatible or on specific mixing instructions to be used with compatible mixes.
This is the combination by the user of two or more products in the same spray tank to obtain better pest control than if the products were applied alone. A positive tank-mix occurs when a product label recommends a mixture to give an enhanced effect when the tank-mix is used (eg to control additional pests; to reduce the application rate of one or more of the products). In such cases, the mix must be shown to be physically and chemically compatible and biologically compatible (effective and crop-safe).
In either case you cannot include recommendations for tank mixes containing 2 or more anticholinesterase products unless we have fully assessed the toxicological effects – you should contact us for guidance on the additional data requirement.
Any convenience tank-mix recommendation, whether on the product label, or provided to users by the authorisation holder verbally or via websites, advertising or other material must be supported by physical and chemical compatibility data. The ASTM standard method is E 1518-05. If another test method is used then it must be justified.
If you are applying for the first authorised label-recommendation of a convenience tank-mix for a product that contains an active substance for which no tank-mixes have been previously authorised in any product, you must submit as part of the application the data and/or reasoned scientific cases demonstrating that the product is physically compatible in the proposed mixture. Full study reports are required.
These data can be considered under the first application to be considered for the active substance (a.s.) or any subsequent application for a product containing that active substance.
Once the first convenience tank-mixture has been authorised for any product with that a.s., subsequent convenience tank-mixes for any products must also be supported by physical compatibility data. However, we do not need to see these data in full but will accept a Compatibility Assurance Statement(CAS) - a statement certifying that data or evidence is available to demonstrate that the products in the proposed mixture are physically compatible. The underlying data must be available for submission if requested by CRD. A CAS must be submitted whenever you submit a new label containing new convenience tank-mixes with an application.
The 'convenience tank-mix' section must make it clear that the listed mixes supported only by physical compatibility data are 'physically and chemically compatible'.
We appreciate that your portfolio of convenience tank-mixtures will increase as new physical compatibility data become available and that it would be difficult to keep updating the authorised label. Therefore, the CAS includes the statement that
We confirm that any additional compatible mixtures that we recommend on the product label, verbally or via websites, advertising or other material will comply with the requirements of paragraphs 2 to 4 above and that these mixtures will be notified to CRD with a new Compatibility Assurance Statement at the next application for this product.
Therefore, whilst your authorised label may include a certain number of convenience mixtures it is acceptable to:
Again, the next time you submit an application, you must submit a CAS with a list of all the convenience tank-mixes that you are currently recommending that do not appear on the label itself.
In addition to the physical and chemical compatibility data required for convenience tank-mixes (see above), where a positive tank-mix recommendation is being made, additional biological compatibility (efficacy) data will be required to support the proposed positive tank-mixes. This also applies to positive tank-mix recommendations made with adjuvants.
Efficacy testing must be conducted in line with the requirements for 'positive tank-mixtures' in Efficacy Guideline 604: Efficacy Data Required for Tank Mixtures and Sequences of Pesticides.
The proposed recommendations must be within the authorised conditions of use of the product to be included in the positive tank-mix recommendation. Otherwise you will also need to submit the appropriate safety data, to amend the authorised conditions of use for the product to be included in the positive tank-mix recommendation.
Positive tank-mix recommendations may only be added to the product label following evaluation of the above data as part of an application to CRD. All data must be submitted in full.
Positive tank mixes may not be recommended in any company literature etc.
The products recommended for 'convenience' or 'positive' tank-mixes on your product label should only be specified in one of the following formats:
In order to provide accurate advice to the user it is essential that any pesticide product recommended as a tank-mixture partner or as a sequential treatment is authorised (refer to CRD's Pesticide Register database). Any reference to products that are no longer authorised must be removed from the product label. For convenience tank mixtures, CRD do not need to be informed, and it is normally acceptable for the changes to be made at the next label reprint. Where authorisation holders become aware that a positive tank-mixture partner or sequence treatment has been withdrawn, they must notify CRD as soon as possible, as this is likely to affect the label recommendations, and possibly the authorisation status of the whole product. CRD will then consider whether a formal application together with a revised label is necessary.